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KMID : 0043320070300050552
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Archives of Pharmacal Research
2007 Volume.30 No. 5 p.552 ~ p.555
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A New Cytotoxic Phenazine Derivative from a Deep Sea Bacterium Bacillus sp.
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Li Dehai
Wang Fengping
Xiao Xiang
Zeng Xiang
Gu Qian-Qun
Zhu Weiming
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Abstract
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A novel phenazine derivative (1) together with six known compounds (2-7) were isolated by bioassay-guided fractionation from the culture broth of a bacterium, Bacillus sp., collected from a Pacific deep sea sediment sample (depth 5059 m). The structures of these compounds were determined using spectroscopic methods. Their cytotoxic effects on P388 and K562 cell lines were preliminarily examined using the sulforhodamine-B (SRB) assay.
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KEYWORD
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Deep sea bacteria, Bacillus sp, Metabolite, Antitumor activities
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